Prolonged Membrane Potential Depolarization in Cingulate Pyramidal Cells after Digit Amputation in Adult Rats
نویسندگان
چکیده
منابع مشابه
Prolonged membrane potential depolarization in cingulate pyramidal cells after digit amputation in adult rats
The anterior cingulate cortex (ACC) plays an important role in higher brain functions including learning, memory, and persistent pain. Long-term potentiation of excitatory synaptic transmission has been observed in the ACC after digit amputation, which might contribute to plastic changes associated with the phantom pain. Here we report a long-lasting membrane potential depolarization in ACC neu...
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Phantom limb pain is experienced by nearly 50 - 80% of the patients following limb amputation. The anterior cingulate cortex (ACC) is a part of the limbic system that is an essential component in mediating the affective and emotional component of pain responses. To explore the role of ACC in the phantom limb pain, we recorded evoked excitatory postsynaptic potentials (EPSPs), cortical network a...
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The anterior cingulate cortex (ACC) is important for cognitive and sensory functions including memory and chronic pain. Glutamatergic excitatory synaptic transmission undergo long-term potentiation in ACC pyramidal cells after peripheral injury. Less information is available for the possible long-term changes in neuronal action potentials or intrinsic properties. In the present study, we charac...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2005
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-1-23